The Lubbock Fire Department responded to a house fire located at 1905 25th Street just before noon on Tuesday.
The fire was located mainly in the attic of the two story structure and proved difficult for firefighters to extinguish.
"Because of the construction of the house, it's real labor intensive and they're having a hard time getting to it," said Deputy Chief Kelly Morman. "They're trying to get to it from the inside and from the top both at the same time. What we're doing, the reason we have so many units on the scene, is we're actually rotating crews in and out because it's just wearing the guys out trying to get it out.
Fire department officials have ruled the fire as accidental.
They say the fire began in the kitchen and made its way to the attic.
The house is a total loss, but the exact cause of the fire is still being determined.
Two people were inside at the time of the fire, but got out safely.
"We've got a family of six, two adults and four children," said Red Cross volunteer Bill Curnow. "Right now we're working with the landlord and working with the family to determine their immediate needs and determine how best to meet them."
Workers with the Lubbock Red Cross noticed the smoke from their office in 2200 block of 19th street. Two staff members and two volunteers responded to the scene.
The Red Cross will not be providing shelter for the family, but will assist with food and clothing. The landlord of the home will be providing the renters a place to stay.
"The family's needs really, we'll determine that in the coming weeks as we start working with other non-profit agencies and those agencies need the support of the public as well," Curnow said.