In the world of chemistry that bathes our brains for good or ill - scientists have uncovered a gene that may cause depression by signaling too many cells to self-destruct. The discovery supports a theory psychiatric researchers have debated for the past several years. "There are certain types of cells in certain parts of the brain that actually would degenerate and die in those who had depression. And so, you have enough of them that die and that part of the brain becomes smaller," says psychiatric researcher, Daniel Christensen. Smaller in this part of the brain called the hippocampus.
Dr. Daniel Christensen says his colleagues have long known genetics play a major role in depression that is passed down in families. Now, with the discovery of this gene - the biological trigger may become even clearer. "Apaf-1 gene is known to be involved with this signal of when it is a cell dies," says Dr. Christensen. All of us experience changes in this part of the brain when we're faced with stressful situations. But among those with a genetic predisposition for depression, certain forms of this gene overreact - commanding cells to die when they're not ready to die. "If this proves out to be true, it would open a whole new arena of pscyhopharmacology," says Dr. Christensen.
What kind of an arena? Medications, according to Myriad, that would block the action of this rogue protein to begin with instead of trying to restore a function that has been lost.
Depression is a group of illnesses that includes depression itself, Bi-Polar disorders and Post Traumatic Stress Syndrome. They afflict 19 million people in this country or about 10 percent of the population.