A major review of research on antidepressants highlights a few medications that seem to work better than others do.
Researchers at the University of Verona in Italy say Zoloft and Lexapro are the most effective with the fewest side effects overall. That comes after analyzing the results of 117 randomized controlled trials from 1991 through 2007. The studies compared the effects of 12 different antidepressants among more than 25,000 patients with major depression.
The study found reboxetine (Edronax) appeared to be least effective. The tested drugs were bupropion (Wellbutrin, Zyban), citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac), fluvoxamine (Luvox), milnacipran, mirtazapine (Remeron), paroxetine (Paxil), reboxetine (Edronax), sertraline (Zoloft) and venlafaxine (Effexor).